THROMBOSIS AND HEMOSTASIS Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort
نویسندگان
چکیده
1Section of Cardiology, Baylor College of Medicine, Houston, TX; 2Department of Biostatistics, University of North Carolina, Chapel Hill, NC; 3Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX; 4Human Genetic Center, University of Texas School of Public Health, Houston, TX; 5Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN; 6National Health Research Institutes, Taipei, Taiwan; 7Section of Cardiovascular Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX; and 8Tianjin Neurology Institute, Tianjin Medical University, Tianjin, China
منابع مشابه
Genetic determinants of plasma von Willebrand factor antigen levels: a target gene SNP and haplotype analysis of ARIC cohort.
von Willebrand factor (VWF) is an essential component of hemostasis and has been implicated in thrombosis. Multimer size and the amount of circulating VWF are known to impact hemostatic function. We associated 78 VWF single nucleotide polymorphisms (SNPs) and haplotypes constructed from those SNPs with VWF antigen level in 7856 subjects of European descent. Among the nongenomic factors, age and...
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1Cardiovascular Sciences Section, Department of Medicine, Baylor College of Medicine, Houston, TX; 2Department of Biostatistics, University of North Carolina, Chapel Hill, NC; 3Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX; 4Human Genetic Center, The University of Texas School of Public Health, Houston, TX; 5Puget Sound Blood...
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OBJECTIVE This study examines the hypothesis that chronic inflammation is associated with a higher risk of cardiac death compared to the risk of nonfatal myocardial infarction. METHODS AND RESULTS Cardiac death and nonfatal MI events were identified in the ARIC cohort during follow-up from 1987 through 2001. Markers of inflammation and hemostasis were determined at baseline using standardized...
متن کاملFunction of von Willebrand factor after crossed bone marrow transplantation between normal and von Willebrand disease pigs: effect on arterial thrombosis in chimeras.
von Willebrand factor (vWF) is essential for the induction of occlusive thrombosis in stenosed and injured pig arteries and for normal hemostasis. To separate the relative contribution of plasma and platelet vWF to arterial thrombosis, we produced chimeric normal and von Willebrand disease pigs by crossed bone marrow transplantation; von Willebrand disease (vWD) pigs were engrafted with normal ...
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